Archive for September, 2009

Orlistat (alli) does not cause liver disease

Posted on September 5, 2009. Filed under: 1, diet, obesity, weight | Tags: , , , |

Orlistat, the active component of alli, has been more extensively studied than any other drug approved for treatment of obesity. Over 30,000 individuals have participated in more than 100 clinical research studies. These studies have measured tests of liver function and have not indicated that orlistat is associated with adverse effects on the liver. In fact, medical doctors who specialize in liver disease have used orlistat for treatment of several types of liver disease. “Fatty liver disease”, accumulation of excessive fat in the liver is very common in overweight individuals. Liver specialists have tested orlistat for treatment of fatty liver and preliminary results from about a dozen studies suggest that orlistat decreases fat accumulation in the liver and improves chemical tests of liver function. Extremely rarely, several different types of liver problems have occurred when individuals have taken orlistat but, currently, there is no specific information indicating that orlistat has been related to these liver problems. There are several reasons that overweight persons could develop liver problems while on a weight-loss diet. Most overweight people have excessive fat in the liver; when they lose weight there often are mild, temporary changes in liver function. Overweight persons are a high risk for gallstones and when they lose weight they commonly form new gallstones. Use of weight loss herbal remedies, other drugs, or alcohol could contribute to liver problems. The current evidence indicates that it is extremely unlikely that individuals who do not have liver problems would be at risk for liver problems while using orlistat.

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